A single double-strand break system reveals repair dynamics and mechanisms in heterochromatin and euchromatin
نویسندگان
چکیده
منابع مشابه
A single double-strand break system reveals repair dynamics and mechanisms in heterochromatin and euchromatin.
Repair of DNA double-strand breaks (DSBs) must be properly orchestrated in diverse chromatin regions to maintain genome stability. The choice between two main DSB repair pathways, nonhomologous end-joining (NHEJ) and homologous recombination (HR), is regulated by the cell cycle as well as chromatin context.Pericentromeric heterochromatin forms a distinct nuclear domain that is enriched for repe...
متن کاملSilencing , Heterochromatin , and DNA Double Strand Break Repair in
The repair of damaged DNA is a crucial function carried out by all cells. Unrepaired DNA damage can lead to mutation, loss of genetic information, cellular transformation, or cell death. The DNA double strand break (DSB) is one type of damage that must be efficiently and accurately repaired. Two general mechanisms are employed by eukaryotic cells to repair DSBs: homologous recombination and non...
متن کاملDouble strand break repair.
DNA double-strand breaks (DSBs) are the most dangerous form of DNA damage and can lead to death, mutation, or malignant transformation. Mammalian cells use three major pathways to repair DSBs: homologous recombination (HR), classical nonhomologous end joining (C-NHEJ), and alternative end joining (A-NHEJ). Cells choose among the pathways by interactions of the pathways with CtIP and 53BP1. HR i...
متن کاملMechanisms of double-strand break repair in somatic mammalian cells.
DNA chromosomal DSBs (double-strand breaks) are potentially hazardous DNA lesions, and their accurate repair is essential for the successful maintenance and propagation of genetic information. Two major pathways have evolved to repair DSBs: HR (homologous recombination) and NHEJ (non-homologous end-joining). Depending on the context in which the break is encountered, HR and NHEJ may either comp...
متن کاملDNA Double-Strand Break Repair
ownloade C regulates a myriad of genes controlling cell proliferation, metabolism, differentiation, and apoptosis. lso controls the expression of DNA double-strand break (DSB) repair genes and therefore may be a ial target for anticancer therapy to sensitize cancer cells to DNA damage or prevent genetic instability. report, we studied whether MYC binds to DSB repair gene promoters and modulates...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Genes & Development
سال: 2016
ISSN: 0890-9369,1549-5477
DOI: 10.1101/gad.283028.116